Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides. (12th January 2014)

• Record Type: Journal Article
• Authors: Attia, Mohamed I.; Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Maklad, Yousreya A.; Ghabbour, Hazem A.
• Other Names: Abouzid K. Academic Editor.; Acquas E. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2014(2014)
• Publication Date: 2014-01-12
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1155/2014/357403
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned ( E )-configuration of the title compounds 6a–p was confirmed via single crystal X-ray structure of compound 6g .