The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis. Issue 17 (9th August 2019)

• Record Type: Journal Article
• Authors: Duciel, Laura; Monraz Gomez, Luis Cristobal; Kondratova, Maria; Kuperstein, Inna; Saule, Simon
• Is Part Of: Journal of molecular biology. Volume 431:Issue 17(2019)
• Page Start: 3056
• Page End: 3067
• Publication Date: 2019-08-09
• Subjects: PTP4A3 protein tyrosine phosphatase 4A3 -- PRL phosphatase of regenerating liver -- EMT epithelial-to-mesenchymal transition -- PTP protein tyrosine phosphatase -- MMPs metalloproteinases; phosphatase -- signaling pathways -- tumorigenesis -- metastasis -- systems biology; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2019.06.008
• Languages: English
• ISSNs: 0022-2836

Abstract

Abstract: PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified that PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell cycle, survival, angiogenesis, adhesion, cytoskeleton remodeling, EMT, motility and invasion, has been reported. Furthermore, several molecules acting as direct or indirect substrates have been identified. However, this information was obtained in many different studies, and it remains difficult to see the larger picture. We therefore systematically collected the published information together and used it to develop a comprehensive signaling network map. By analyzing this network map, we were able to retrieve the signaling pathways via which PRL-3 governs the key steps of the metastatic process in cancer. In this review, we summarize current knowledge of the role of PRL-3 in cancer and the molecular mechanisms involved. We also provide the web-based open-source PRL-3 signaling network map, for use in further studies. Graphical Abstract: Unlabelled Image Highlights: The phosphatase PRL-3 regulates numerous pathways driving tumorigenesis and metastasis.