Bleomycin use in the treatment of Hodgkin lymphoma (HL): toxicity and outcomes in the modern era. Issue 2 (28th January 2020)

• Record Type: Journal Article
• Authors: Taparra, Kekoa; Liu, Heshan; Polley, Mei-Yin; Ristow, Kay; Habermann, Thomas M.; Ansell, Stephen M.
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 2(2020)
• Page Start: 298
• Page End: 308
• Publication Date: 2020-01-28
• Subjects: Hodgkin lymphoma -- lung toxicity -- bleomycin -- chemotherapy toxicity -- ABVD; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2019.1663419
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: One-in-five Hodgkin Lymphoma (HL) patients treated with bleomycin develop bleomycin pulmonary toxicity (BPT). Given bleomycin-omission data with negative interim-PET, we assessed changes in BPT statistics. We retrospectively evaluated 126 ABVD-treated HL patients for overall survival (OS), progression-free survival (PFS), BPT factors, and management. Forty-seven patients developed BPT with 17% BPT-mortality. In univariable analysis, OS was negatively impacted by BPT (HR = 3.6, 95%CI = 1.2–10.6), but not bleomycin-omission (HR = 1.3, 95%CI = 0.5–3.7). In multivariable analysis, BPT was not associated with OS (HR = 3.0, 95%CI = 0.9–9.9). BPT patients were older (46 y vs 33 years) and received less bleomycin (107 vs 215 units) compared to non-BPT patients. BPT was managed primarily with bleomycin-omission. "Recent Era" patients had lower BPT rates (28% vs 48%), mortality (10% vs 21%), and bleomycin doses (7 vs 12 doses), yet higher bleomycin-omission in the absence of the BPT (59% vs 8%) compared to "Early Era". Our data suggest BPT continually impacts OS in ABVD-treated HL patients, however management is changing.