Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2, 6-disubstituted-5-azaindoles. Issue 3 (1st February 2019)
- Record Type:
- Journal Article
- Title:
- Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2, 6-disubstituted-5-azaindoles. Issue 3 (1st February 2019)
- Main Title:
- Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2, 6-disubstituted-5-azaindoles
- Authors:
- Balfour, Michael N.
Zukerman-Schpector, Julio
Rodriguez, Maria José Dávila
Reis, Joel Savi
Esteves, Carlos Henrique A.
Stefani, Hélio A. - Abstract:
- Abstract: The synthesis of a library of 2, 6-disubstituted-azaindoles relying on Sonogashira cross-coupling and intramolecular cyclization is described. Eleven examples of 6-alkynyl derivatives and three examples of 3-bromo-5-azaindoles are reported. One of the 3-bromo-5-azaindoles was also further functionalized with two different aryl trifluoroborate salts via Suzuki-Miyaura coupling reaction. Graphical Abstract:
- Is Part Of:
- Synthetic communications. Volume 49:Issue 3(2019)
- Journal:
- Synthetic communications
- Issue:
- Volume 49:Issue 3(2019)
- Issue Display:
- Volume 49, Issue 3 (2019)
- Year:
- 2019
- Volume:
- 49
- Issue:
- 3
- Issue Sort Value:
- 2019-0049-0003-0000
- Page Start:
- 351
- Page End:
- 358
- Publication Date:
- 2019-02-01
- Subjects:
- Alkynes -- cyclization -- heterocycle -- Sonogashira -- tandem reaction
Organic compounds -- Synthesis -- Periodicals
Chemistry, Organic
Synthesis
547.205 - Journal URLs:
- http://www.tandfonline.com/toc/lsyc20/current ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/00397911.2018.1545032 ↗
- Languages:
- English
- ISSNs:
- 0039-7911
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8586.830000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 17107.xml