Design and synthesis of cage-like NADH model molecule intermediate with multi-chiral centers. Issue 3 (1st February 2019)

• Record Type: Journal Article
• Authors: Zhang, Tong; Bai, Cui-Bing; Wu, Yue-Hua; Wang, Nai-Xing; Xu, Bao-Cai; Yan, Zhan; Xing, Yalan
• Is Part Of: Synthetic communications. Volume 49:Issue 3(2019)
• Page Start: 410
• Page End: 416
• Publication Date: 2019-02-01
• Subjects: Cage-like -- multi-chiral centers -- NADH -- symmetry -- intermediate; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2018.1557689
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Studying NADH molecules is one of the most active areas in biomimetic research. It is important to design novel and efficient chiral NADH model molecules. Herein, a cage-like NADH model with multi-chiral centers was designed, and key intermediates have been synthesized. In this study, we found that pentafluorophenoxy group is an excellent leaving group for our synthetic route. GRAPHICAL ABSTRACT: