Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators. (4th March 2019)

• Record Type: Journal Article
• Authors: Preussner, Jens; Zhong, Jiasheng; Looso, Mario; Braun, Thomas; Kim, Johnny
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 2(2019)
• Publication Date: 2019-03-04
• Subjects: Cell of origin -- muscle -- stem cell -- regeneration -- genomic instability -- rhabdomyosarcoma -- zygotic gene activation -- Duxbl -- DUXB -- DUX4 -- TP53 -- MET; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1565469
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: How, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic transcription factor Duxbl / DUXB to initiate tumorigenic transformation.