A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Sreenivasulu, Chinnabattigalla; Thadathil, Ditto Abraham; Pal, Sumit; Gedu, Satyanarayana
• Is Part Of: Synthetic communications. Volume 50:Issue 1(2020)
• Page Start: 112
• Page End: 122
• Publication Date: 2020-01-02
• Subjects: 4H-chromenes -- phenol -- ketones -- chalcones -- Lewis acid; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2019.1689268
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Lewis acid ZnCl2 promoted cyclization protocol to 4 H -chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4 H -chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho -benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols. Graphical Abstract: