Mild, Selective Ru‐Catalyzed Deuteration Using D2O as a Deuterium Source. Issue 72 (28th November 2019)

• Record Type: Journal Article
• Authors: Eisele, Pascal; Ullwer, Franziska; Scholz, Sven; Plietker, Bernd
• Is Part Of: Chemistry. Volume 25:Issue 72(2019)
• Page Start: 16550
• Page End: 16554
• Publication Date: 2019-11-28
• Subjects: catalysis -- C−H activation -- deuterium -- isotopes -- ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201904927
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2 (PPh3 )3 ] and D2 O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru‐complexes under the given specific conditions. Abstract : C−H activation : A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2 (PPh3 )3 ] and D2 O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed (see scheme).