Post marathon cardiac troponin T is associated with relative exercise intensity. Issue 9 (September 2018)

• Record Type: Journal Article
• Authors: Richardson, A.J.; Leckie, T.; Watkins, E.R.; Fitzpatrick, D.; Galloway, R.; Grimaldi, R.; Baker, P.
• Is Part Of: Journal of science and medicine in sport. Volume 21:Issue 9(2018)
• Page Start: 880
• Page End: 884
• Publication Date: 2018-09
• Subjects: Heart -- Endurance -- Stress -- Cardiopulmonary fitness -- Running; Sports sciences -- Periodicals; Sports medicine -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports -- physiology -- Periodicals; Sports Medicine -- Periodicals; Sportgeneeskunde; 617.102705
• DOI: 10.1016/j.jsams.2018.02.005
• Languages: English
• ISSNs: 1440-2440

Abstract

Abstract: Objectives: This study aimed to investigate whether measures of cardiopulmonary fitness and relative exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a road marathon. Methods: Fifty-two marathon runners (age 39 ± 11 years, body mass 76.2 ± 12.9 kg, height 1.74 ± 0.09 m) attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Running economy at 10 km h −1 (RE10) and race pace (RERP), ventilatory threshold (VT) and VO2 max tests were completed. CTnT was measured within 48 h prior to the marathon and within 10 min of completing the marathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon. Results: Runners demonstrated a significant increase in cTnT over the marathon (pre-race 5.60 ± 3.27 ng L −1, post-race 74.52 ± 30.39 ng L −1, p < 0.001). Markers of endurance performance such as running economy (10 km h −1 223 ± 18 ml kg −1 km −1 ; race pace 225 ± 22 ml kg −1 km −1 ), VT (38.5 ± 6.4 ml kg −1 min −1 ) and V ˙ O2 max (50.9 ± 7.7 ml kg −1 min −1 ) were not associated with post-race cTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104 ± 5%, r = 0.50; peak HR %VT 118 ± 8%, r = 0.68; peak HR % V ˙ O2 max 96 ± 6, r = 0.60, p < 0.05) and was different between the low, medium and high cTnT groups ( p < 0.05). Conclusions: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related to exercise intensity relative to ventilatory threshold and V ˙ O2 max, but not individuals' absolute cardiopulmonary fitness, training state or running history.