Lifestyle factors do not explain the difference on diabetes progression according to type of prediabetes: Results from a Spanish prospective cohort of prediabetic patients. (July 2019)

• Record Type: Journal Article
• Authors: Ezquerra-Lázaro, Isabel; Cea-Soriano, Lucía; Giraldez-García, Carolina; Ruiz, Antonio; Franch-Nadal, Josep; Diez-Espino, Javier; Nogales, Pedro; Carramiñana, Francisco; Javier Sangros, F.; Regidor, Enrique
• Is Part Of: Diabetes research and clinical practice. Volume 153(2019)
• Page Start: 66
• Page End: 75
• Publication Date: 2019-07
• Subjects: ADA American Diabetes Association -- BMI Body mass index -- CI Confidence Interval -- FPG Fasting plasma glucose -- IFG Impaired fasting glucose -- IGT Impaired glucose tolerance -- HbA1c Glycated hemoglobin A1c -- HDL-C High-density lipoprotein cholesterol -- HR Hazard ratio -- HTG Hypertriglyceridemia -- HTN Hypertension -- OGTT Oral glucose tolerance test -- PREDAPS Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes in Spain -- SD Standard deviation -- T2DM Type 2 diabetes mellitus -- WHO World Health Organization; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.05.033
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: We studied the role of lifestyle factors associated to type 2 diabetes (T2DM) onset according to type of prediabetes. Methods: We used data from the observational prospective cohort study in Primary Health Care on the Evolution of Patients with Prediabetes in Spain (PREDAPS). Participants were classified by American Diabetes Association criteria using either fasting plasma glucose levels (100–125 mg/dL) (group 1), HbA1c (5.7%–6.4%) (group 2) or both impaired parameters (group 3). Relationship between lifestyles and diabetes onset according to prediabetes at third year of follow up were estimated by Hazard Ratios (HRs) using three sequential models. Results: Incidence rate of diabetes was 2.27 cases per 1000 person-years (95% CI: 1.4–3.6) for group 1, 1.18 (95% CI: 0.65–2.13) for group 2 and 6.68 (95% CI: 5.71–8.23) for group 3. The most important risk factors were: abdominal obesity (HR: 2.29 (95% CI: 1.49–3.52)) and hypertension (HR: 2.16 (95% CI: 1.41–3.30)). Using as reference group 2, group 3 had a HR of 5.82 (3.13–10.82) and 1.83 (95% CI: 0.85–3.93) for group 1, estimates remained constant when adjusting by lifestyle and metabolic factors. Conclusions: Lifestyle and metabolic do not seem to explain the differences on T2DM onset by type of prediabetes.