Pharmacokinetic Analysis of [18F]FAZA Dynamic PET Imaging Acquisitions for Highlighting Sacrum Tumor Profiles. (January 2020)

• Record Type: Journal Article
• Authors: Provost, Claire; Mammar, Hamid; Belly-Poinsignon, Anne; Madar, Olivier; Champion, Laurence
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 1(2020)
• Publication Date: 2020-01
• Subjects: [18F]FAZA -- chordoma -- paraganglioma -- pharmacokinetics imaging -- PET; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002813
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A patient enrolled in a clinical trial (NCT02802969) with suspicion of chordoma underwent an [ 18 F]FAZA PET/CT, a radiolabeled nitroimidazole analog of hypoxia PET imaging. The patient's images showed a different tumor profile compared to those observed in other hypoxic or nonhypoxic chordoma patients. The motivation for using [ 18 F]FAZA pharmacokinetic imaging was to compare this profile with histologically confirmed cases of chordoma. Through visual imaging and quantification of blood and tumor time-activity curves, we excluded the hypothesis that it was a chordoma, diagnosing a paraganglioma.