Ameliorative effect of Cyclocarya paliurus polysaccharides against carbon tetrachloride induced oxidative stress in liver and kidney of mice. (January 2020)

• Record Type: Journal Article
• Authors: Wu, Ting; Shen, Mingyue; Liu, Shihua; Yu, Qiang; Chen, Yi; Xie, Jianhua
• Is Part Of: Food and chemical toxicology. Volume 135(2020)
• Publication Date: 2020-01
• Subjects: Cyclocarya paliurus polysaccharides -- Oxidative stress -- Liver -- Kidney; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.111014
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Chemical liver and kidney injury have become a serious concern to human. Side effects occur when they are treated with medicine. The present study evaluated the preventive effect of Cyclocarya paliurus polysaccharides (CP) on hepatic and renal injury in carbon tetrachloride (CCl4 ) induced mice. The results showed that CP treatment could effectively prevent H2 O2 -induced oxidative damage of NCTC-1469 cells. Administrated with CP could ameliorate the body weight loss and organ swelling of mice induced by the 0.2% CCl4 . Compared with the model group, CP groups have beneficial effects in decreasing ALT, AST, TBA and CRE levels in serum. In addition, the expression of CYP2E1 in the liver was also significantly decline after continuous administration of CP. Moreover, pre-administration of CP can improve the antioxidant status of liver and kidney (MDA and SOD, GSH-Px). Histopathological studies also supported the improvement of CP on liver and kidney of CCl4 -induced mice. These results indicate that CP may be of therapeutic value in ameliorating the hepatic and renal oxidative stress caused by CCl4, through its antioxidant properties. Graphical abstract: Image 1 Highlights: CP attenuated oxidative stress induced by H2 O2 on NCTC-1469 hepatocytes. CCl4 induced liver and kidney damage in mice. CP effectively alleviated CCl4 -induced liver and kidney toxicity. CP suppressed the CYP2E1 expression in CCl4 induced mice. CP attenuated CCl4 -induced oxidative stress in liver and kidney of mice.