Urine selenium concentration is a useful biomarker for assessing population level selenium status. (January 2020)

• Record Type: Journal Article
• Authors: Phiri, Felix P.; Ander, E. Louise; Lark, R. Murray; Bailey, Elizabeth H.; Chilima, Benson; Gondwe, Jellita; Joy, Edward J.M.; Kalimbira, Alexander A.; Phuka, John C.; Suchdev, Parminder S.; Middleton, Daniel R.S.; Hamilton, Elliott M.; Watts, Michael J.; Young, Scott D.; Broadley, Martin R.
• Is Part Of: Environment international. Volume 134(2020)
• Publication Date: 2020-01
• Subjects: Biomarkers -- Biomonitoring -- Micronutrient survey -- Selenium status -- Sub Saharan Africa -- Urine; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2019.105218
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: Selenium (Se) concentration is a potential biomarker for assessing Se status at a population level in a low Se-status population. VZ Variation in urine and plasma Se concentration of women and school aged children in Malawi corresponded between clusters between bet. Urine Se concentration explained more of the between-cluster variation in plasma Se concentration when data were corrected for hydration status. UU Urine Se concentration is a less useful biomarker at an individual level. Abstract: Plasma selenium (Se) concentration is an established population level biomarker of Se status, especially in Se-deficient populations. Previously observed correlations between dietary Se intake and urinary Se excretion suggest that urine Se concentration is also a potentially viable biomarker of Se status. However, there are only limited data on urine Se concentration among Se-deficient populations. Here, we test if urine is a viable biomarker for assessing Se status among a large sample of women and children in Malawi, most of whom are likely to be Se-deficient based on plasma Se status. Casual (spot) urine samples (n = 1406) were collected from a nationally representative sample of women of reproductive age (WRA, n =741) and school aged children (SAC, n=665) across Malawi as part of the 2015/16 Demographic and Health Survey. Selenium concentration in urine was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary dilution corrections for specific gravity, osmolality, and creatinine were applied to adjust for hydration status. Plasma Se status had been measured for the same survey participants. There was between-cluster variation in urine Se concentration that corresponded with variation in plasma Se concentration, but not between households within a cluster, or between individuals within a household. Corrected urine Se concentrations explained more of the between-cluster variation in plasma Se concentration than uncorrected data. These results provide new evidence that urine may be used in the surveillance of Se status at the population level in some groups. This could be a cost-effective option if urine samples are already being collected for other assessments, such as for iodine status analysis as in the Malawi and other national Demographic and Health Surveys.