Studying immune to non-immune cell cross-talk using single-cell technologies. Issue 18 (December 2019)

• Record Type: Journal Article
• Authors: Elmentaite, R.; Teichmann, S.A.; Madissoon, E.
• Is Part Of: Current opinion in systems biology. Issue 18(2019)
• Page Start: 87
• Page End: 94
• Publication Date: 2019-12
• Subjects: Single-cell technologies -- Immunity -- Cell-cell interactions -- Cross-talk applications; Systems biology -- Periodicals; 570
• DOI: 10.1016/j.coisb.2019.10.005
• Languages: English
• ISSNs: 2452-3100

Abstract

Abstract: Single-cell RNA-sequencing has uncovered immune heterogeneity, including novel cell types, states and lineages that have expanded our understanding of the immune system as a whole. More recently, studies involving both immune and non-immune cells have demonstrated the importance of immune microenvironment in development, homeostasis and disease. This review focuses on the single-cell studies mapping cell–cell interactions for variety of tissues in development, health and disease. In addition, we address the need to generate a comprehensive interaction map to answer fundamental questions in immunology as well as experimental and computational strategies required for this purpose. Highlights: Systems view of immunology achieved via studying cell–cell interactions by single-cell methods. Importance of studying immune vs niche cell cross-talk in development, homeostasis and disease. Outlook of single-cell technologies in interrogating immune to niche cell cross-talk.