Analysis of the thermal response and requirement for power dissipation in magnetic hyperthermia with the effect of blood temperature. (November 2018)

• Record Type: Journal Article
• Authors: Liu, Kuo-Chi; Chen, Tse-Min
• Is Part Of: International journal of heat and mass transfer. Volume 126(2018)Part B
• Page Start: 1048
• Page End: 1056
• Publication Date: 2018-11
• Subjects: Generalized dual-phase-lag model -- Power dissipation -- Tumor hyperthermia -- Transient blood temperature; Heat -- Transmission -- Periodicals; Mass transfer -- Periodicals; Chaleur -- Transmission -- Périodiques; Transfert de masse -- Périodiques; Electronic journals; 621.4022
• DOI: 10.1016/j.ijheatmasstransfer.2018.06.024
• Languages: English
• ISSNs: 0017-9310

Abstract

Highlights: The generalized dual-phase-lag model of bioheat transfer in a two-layer concentric medium is solved. The effects of time-dependent blood temperature and size of tumor are investigated. The suitable power dissipation is estimated for a sustained treatment temperature. A hybrid numerical scheme is proposed for such a problem. Abstract: Magnetic hyperthermia has been an oncological technique. To know the heat transport occurring in biological tissues during hyperthermia treatment is essential for its improvement. The biological tissue can be treated as a fluid saturated porous medium. Therefore, this work applies the generalized dual-phase-lag model of bioheat transfer, which was derived from a two-temperature model, to describe the behavior of bioheat transfer in the tumor and its surrounding healthy tissue with transient blood temperature during hyperthermia treatment. A hybrid numerical scheme based on the Laplace transform is proposed to solve the present problem. The effect of porosity, coupling factor, metabolic heat generation, time-dependent blood temperature, and size of tumor on the thermal response is investigated. The suitable power dissipation is also estimated for a sustained temperature which could ablate the tumor without damaging surrounding healthy tissues. In order to show the effect of blood temperature, the comparison between the results with the transient blood temperature and those with the constant blood temperature is done.