Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments. (18th May 2021)

• Record Type: Journal Article
• Authors: Xiang, Mi; Lu, Yingdong; Xin, Laiyun; Gao, Jialiang; Shang, Chang; Jiang, Zhilin; Lin, Hongchen; Fang, Xuqin; Qu, Yi; Wang, Yuling; Shen, Zihuan; Zhao, Mingjing; Cui, Xiangning
• Other Names: Tocchetti Carlo G. Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2021(2021)
• Publication Date: 2021-05-18
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2021/6614009
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is currently the standard intervention. However, the reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MI/RI). Oxidative stress is one of the most important pathological mechanisms in reperfusion injury, which causes apoptosis, autophagy, inflammation, and some other damage in cardiomyocytes through multiple pathways, thus causing irreversible cardiomyocyte damage and cardiac dysfunction. This article reviews the pathological mechanisms of oxidative stress involved in reperfusion injury and the interventions for different pathways and targets, so as to form systematic treatments for oxidative stress-induced myocardial reperfusion injury and make up for the lack of monotherapy.