The Mechanism Underlying the Extreme Sensitivity of Duck to Aflatoxin B1. (17th May 2021)

• Record Type: Journal Article
• Authors: Wu, Kuntan; Liu, Minjie; Wang, Huanbin; Rajput, Shahid Ali; Shan, Yajing; Qi, Desheng; Wang, Shuai
• Other Names: Ali Daoud Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2021(2021)
• Publication Date: 2021-05-17
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2021/9996503
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Most metabolites of aflatoxin B1 (AFB1 ), especially exo-AFB1 -8, 9-epoxide (AFBO), can induce the production of reactive oxygen species (ROS) to vary degrees, causing oxidative stress and liver damage, and ultimately induce liver cancer in humans and animals. Duck is one of the most sensitive animals to AFB1, and severe economic losses are caused by duck AFB1 poisoning every year, but the exact mechanism of this high sensitivity is still unclear. This review highlights significant advances in our understanding of the AFB1 metabolic activation, like cytochrome P450s (CYPs), and AFB1 metabolic detoxification, like glutathione S-transferases (GSTs) in poultry. In addition, AFB1 may have other metabolic pathways in poultry, such as the mutual conversion of AFB1 and aflatoxicol (AFL) and the process of AFBO to produce AFB1 -8, 9-dihydrodiol (AFB1 -dhd) and further metabolize it into detoxification substances. This review also summarized some exogenous regulatory substances that can alleviate AFB1 -induced oxidative stress.