Regulatory T cells: Possible mediators for the anti-inflammatory action of statins. (November 2019)

• Record Type: Journal Article
• Authors: Shahbaz, Sanaz Keshavarz; Sadeghi, Mahvash; Koushki, Khadije; Penson, Peter E.; Sahebkar, Amirhossein
• Is Part Of: Pharmacological research. Volume 149(2019)
• Publication Date: 2019-11
• Subjects: ACS acute coronary syndromes -- APC antigen presenting cells -- ApoE apolipoprotein (a) -- ATP adenosine triphosphate -- ATRA all-trans retinoic acid -- BALF bronchoalveolar lavage fluid -- BCG Bacille Calmette–Guérin -- BMDC bone marrow-derived DCs -- CNS central nervous system -- CRP C-reactive protein -- DTH delayed-type hypersensitivity -- EAE experimental autoimmune encephalomyelitis -- EAMG experimental autoimmune myasthenia gravis -- ERK extracellular signal-regulated kinases -- FP fluticasone propionate -- FPP farnesyl pyrophosphate -- GARP glycoprotein A repetitions predominant -- GBM glomerular basement membrane -- GGPP geranylgeranyl pyrophosphate -- HFFD high fat fructose diet -- HIV human immunodeficiency virus -- HMG-CoAR hydroxy methyl glutaryl coenzyme A reductase -- IDO indoleamine 2, 3-dioxygenase -- IPEX immune dysregulation, poly endocrinopathy and enteropathy, X-linked syndrome -- IRI ischemia-reperfusion injury -- LDL low-density lipoprotein -- MBP myelin basic protein -- MHC major histocompatibility complex -- MOG myelin oligodendrocyte glycoprotein -- MS multiple sclerosis -- NK natural killer (cells) -- PBMC peripheral blood mononuclear cells -- PCI percutaneous coronary intervention -- PMI periprocedural myocardial infarction -- RA rheumatoid arthritis -- ROCK Rho Associated kinase -- ROR related orphan receptors -- RRMS relapsing-remitting multiple sclerosis -- SCID severe combined immunodeficiency -- STEMI ST-segment elevated myocardial infarction -- TNF tumour necrosis factor -- TolDC tolerogenic dendritic cell; Statins -- Treg -- Immune system -- Autoimmunity; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.104469
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Statins beside their main effect on reducing the progression of cardiovascular disease through pharmacological inhibition of the endogenous cholesterol synthesis, have additional pleiotropic effects including antiinflammatory effects mediated through the induction of suppressor regulatory T cells (Tregs). Statin-induced expansion of Tregs reduces chronic inflammation and may have beneficial effects in autoimmune diseases. However, statins could represent a double-edged sword in immunomodulation. Drugs that act by increasing the concentration of Tregs could enhance the risk of cancers, particularly in the elderly and may have adverse effects in neurodegenerative disorders and infectious diseases. In the present paper, we review the experimental studies that evaluate the effects of statins on Treg cells in autoimmune and inflammatory diseases and we discuss potential therapeutic applications of statins in this setting.