Comparative Study of Cytomorphological Robinson's Grading for Breast Carcinoma with Modified Bloom-Richardson Histopathological Grading. (25th September 2013)

• Record Type: Journal Article
• Authors: Sood, Neelam; Nigam, Jitendra Singh; Yadav, Poonam; Rewri, Shivani; Sharma, Ankit; Omhare, Anita; Malhotra, Jaya
• Other Names: Terracciano Luigi M. Academic Editor.
• Is Part Of: Pathology research international. Volume 2013(2013)
• Publication Date: 2013-09-25
• Subjects: Pathology -- Periodicals; 571.905
• DOI: 10.1155/2013/146542
• Languages: English
• ISSNs: 2090-8091

Abstract

Abstract : Objective . To study the correlation of cytomorphological Robinson's grading for breast cancers with a modified Bloom-Richardson histopathological grading. Materials and Methods . One hundred sixteen cytologically malignant breast tumour cases were included in this study and correlated with paraffin embedded sections. Breast lumps were varied from less than 1 cm to 11 cm in greatest dimension. FNA was performed from different sites of the breast lump, and smears were stained with Giemsa and H&E stain and evaluated for cytological grading according to Robinson's grading system. Paraffin embedded tissue sections were stained with hematoxylin and eosin stain and graded according to modified Bloom-Richardson grading system. Comparison between these two grading systems was done. Results . Cytologically grade I, grade II, and grade III cases were 13.8%, 64.65%, and 21.55%, respectively. Histologically 25%, 54.31%, and 20.69% cases were grade I, grade II, and grade III, respectively. Concordance rate between cytology and histology of grade I, grade II, and grade III tumors was 75%, 70.67%, and 60% respectively. The absolute concordance rate was 68.97%. Conclusion . In the era of multiple treatment modalities and neoadjuvant therapy, cytological grading can be used as a prognostic factor for better management of patients.