ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65. (14th January 2015)

• Record Type: Journal Article
• Authors: Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Guo, Ying-jun; Liu, Yi; Zhang, Wei; Wang, Shuai-shuai; Zhang, Yuan-qiang; Pan, Xin; Nie, Lin
• Other Names: Cantarini Luca Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2015(2015)
• Publication Date: 2015-01-14
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2015/196702
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF- α and NF- κ B signaling pathway. In this study we compared the expression of ADAMTS-7, TNF- α, and Phospho-NF- κ B in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF- α, and Phospho-NF- κ B was significantly upregulated in ONFH patients' articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF- α and Phospho-NF- κ B P65 in cartilage, which may imply its association with cartilage destruction of ONFH.