Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies. (14th May 2012)

• Record Type: Journal Article
• Authors: Trujillo, Kristina A.; Jones, Anna C.; Griffith, Jeffrey K.; Bisoffi, Marco
• Other Names: Gaston Sandra M. Academic Editor.
• Is Part Of: Prostate cancer. Volume 2012(2012)
• Publication Date: 2012-05-14
• Subjects: Prostate -- Cancer -- Periodicals; Prostate -- Cancer -- Surgery -- Periodicals; 616.99463
• DOI: 10.1155/2012/302894
• Languages: English
• ISSNs: 2090-3111

Abstract

Abstract : Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.