Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium. (21st April 2010)

• Record Type: Journal Article
• Authors: Byun, Jae Yong; Yune, Tae Young; Lee, Jee Youn; Yeo, Seung Geun; Park, Moon Suh
• Other Names: Malamitsi-Puchner Ariadne Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2010(2010)
• Publication Date: 2010-04-21
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2010/796315
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-κ B, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-κ B signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-κ B in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In cholesteatoma epithelium, activated NF-κ B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (P < .05 ). Furthermore, a significant inverse correlation was detected between CYLD and activated NF-κ B expression in cholesteatoma epithelium (r = - 0.630 ). We found that CYLD reduced and activated increased NF-κ B in cholesteatoma epithelium in comparison to RA skin. The inverse correlation between CYLD and activated NF-κ B in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia.