Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1, 3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one. (26th May 2014)

• Record Type: Journal Article
• Authors: Attia, Mohamed I.; El-Brollosy, Nasser R.; Kansoh, Amany L.; Ghabbour, Hazem A.; Al-Wabli, Reem I.; Fun, Hoong-Kun
• Other Names: Arslan Hakan Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2014(2014)
• Publication Date: 2014-05-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2014/457430
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Synthesis, X-ray structure and antimicrobial activity of 6-(1, 3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3 H )-one (8 ) are reported. Compound 8 exhibited activity towards S. aureus with MIC value of 0.0619 μ mol/mL while it showed activity towards B. subtilis, B. cereus, C. albicans, and A. niger with MIC = 0.1859 μ mol/mL. Single crystal X-ray structure of the title compound 8 confirmed its S -alkylation. The title compound crystallizes in the triclinic, P -1, a = 11.1220 (5) Å, b = 12.2241 (5) Å, c = 21.5246 (9) Å, α = 88.958 (2)°, β = 79.836 (2)°, γ = 79.384 (2)°, V = 2830.9 (2) Å 3, Z = 6, R ( F ) = 0.046, w R ( F 2 ) = 0.110, T = 100 K. The crystal structure is stabilized by weak intermolecular C–H⋯ O and N–H⋯ O hydrogen interactions.