LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone. (5th July 2011)

• Record Type: Journal Article
• Authors: Enomoto, Mika; Adachi, Hisashi; Hirai, Yuji; Fukami, Ako; Satoh, Akira; Otsuka, Maki; Kumagae, Shun-Ichi; Nanjo, Yasuki; Yoshikawa, Kuniko; Esaki, Eishi; Kumagai, Eita; Ogata, Kinuka; Kasahara, Akiko; Tsukagawa, Eri; Yokoi, Kanako; Ohbu-Murayama, Kyoko; Imaizumi, Tsutomu
• Other Names: Chroni Angeliki Academic Editor.
• Is Part Of: Journal of lipids. Volume 2011(2011)
• Publication Date: 2011-07-05
• Subjects: Lipids -- Periodicals; Lipids; Lipids; Electronic journals; Periodicals; Periodicals; 572.57
• DOI: 10.1155/2011/549137
• Languages: English
• ISSNs: 2090-3030

Abstract

Abstract : High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are strong predictors of atherosclerosis. Statin-induced changes in the ratio of LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than LDL-C or HDL-C alone. However, the best predictor of subclinical atherosclerosis remains unknown. Our objective was to investigate this issue by measuring changes in carotid intima-media thickness (IMT). A total of 1, 920 subjects received health examinations in 1999, and were followed up in 2007. Changes in IMT (follow-up IMT/baseline IMT × 100 ) were measured by ultrasonography. Our results showed that changes in IMT after eight years were significantly related to HDL-C (inversely, P < 0.05 ) and to LDL-C/HDL-C ratio (P < 0.05 ). When the LDL-C/HDL-C ratios were divided into quartiles, analysis of covariance showed that increases in the ratio were related to IMT progression (P < 0.05 ). This prospective study demonstrated the LDL-C/HDL-C ratio is a better predictor of IMT progression than HDL-C or LDL-C alone.