Cytotoxic Effect of Nanocrystalline MgFe2O4 Particles for Cancer Cure. (17th December 2013)

• Record Type: Journal Article
• Authors: Kanagesan, S.; Hashim, M.; Tamilselvan, S.; Alitheen, N. B.; Ismail, I.; Bahmanrokh, G.
• Other Names: Yu William W. Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2013(2013)
• Publication Date: 2013-12-17
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2013/865024
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Nanocrystalline magnesium ferrites (MgFe2 O4 ) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2 O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μ g/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2 O4 nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2 O4 nanoparticles in 800 μ g/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.