Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds. (5th November 2013)

• Record Type: Journal Article
• Authors: Zhang, Xuehui; Xu, Mingming; Liu, Xinggang; Zhang, Feng; Wei, Yan; Meng, Song; Dai, Xiaohan; Duan, Aizhu; Deng, Xuliang
• Other Names: Chen Haifeng Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2013(2013)
• Publication Date: 2013-11-05
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2013/913438
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Nano- β -tricalcium phosphate/collagen (n- β -TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n- β -TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n- β -TCP/Col scaffolds exhibited high biocompatibility in vitro . The introduction of BMSCs expanded in vitro to the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n- β -TCP/Col scaffolds have the potential to be applied in bone tissue engineering.