Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study. (17th May 2012)

• Record Type: Journal Article
• Authors: Tomitaka, Asahi; Yamada, Tsutomu; Takemura, Yasushi
• Other Names: Vasilev Krasimir Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2012(2012)
• Publication Date: 2012-05-17
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2012/480626
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe 3 O 4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe 3 O 4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated Fe 3 O 4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.