Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults. (26th December 2013)

• Record Type: Journal Article
• Authors: Mishra, Suruchi; Harris, Tamara B.; Hue, Trisha; Miljkovic, Iva; Satterfield, Suzanne; de Rekeneire, Nathalie; Mehta, Mira; Sahyoun, Nadine R.
• Other Names: Zemel Michael B. Academic Editor.
• Is Part Of: Journal of nutrition and metabolism. Volume 2013(2013)
• Publication Date: 2013-12-26
• Subjects: Nutrition -- Periodicals; Metabolism -- Periodicals; Diet in disease -- Periodicals; Metabolic Diseases; Metabolism; Nutrition Disorders; Nutritional Sciences; Diet in disease; Metabolism; Nutrition; Electronic journals; Periodicals; Periodicals; 363.8
• DOI: 10.1155/2013/327079
• Languages: English
• ISSNs: 2090-0724

Abstract

Abstract : Background . Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines. Methods . The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cytokines, BMI, total percent fat, and visceral and subcutaneous fat. Multivariate logistic regression was used to determine the association between leptin and metabolic syndrome (defined per NCEP ATP III) incidence after 6 years of follow-up among 1, 120 men and women. Results . Leptin predicted metabolic syndrome in men (P for trend = 0.0002) and women (P for trend = 0.0001). In women, risk of metabolic syndrome increased with higher levels of leptin (compared with quintile 1, quintile 2 RR = 3.29, CI = 1.36, 7.95; quintile 3 RR = 3.25, CI = 1.33, 7.93; quintile 4 RR = 5.21, CI = 2.16, 12.56; and quintile 5 RR = 7.97, CI = 3.30, 19.24) after adjusting for potential confounders. Leptin remained independently associated with metabolic syndrome risk after additional adjustment for adiposity, cytokines, and CRP. Among men, this association was no longer significant after controlling for adiposity. Conclusion . Among older women, elevated concentrations of leptin may increase the risk of metabolic syndrome independent of adiposity and cytokines.