A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge. Issue 12 (31st May 2021)

• Record Type: Journal Article
• Authors: Zhao, Peng; Lou, Li-Li; Zhang, Hao; Guo, Rui; Wang, Xiao-Bo; Huang, Xiao-Xiao; Song, Shao-Jiang
• Is Part Of: Natural product research. Volume 35:Issue 12(2021)
• Page Start: 2112
• Page End: 2115
• Publication Date: 2021-05-31
• Subjects: Crataegus pinnatifida -- dineolignan -- structure elucidation -- Aβ1‐42 aggregation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1655415
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new dineolignan, crataeguslignan A (1 ), along with one known dineolignan (2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their A β 1–42 inhibition activity. Among them, 1 displayed the most potent A β 1–42 inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 μM. Graphical Abstract: