Doxapram Hydrochloride Aggravates Adrenaline-Induced Arrhythmias Accompanied by Bidirectional Ventricular Tachycardia. (9th January 2014)

• Record Type: Journal Article
• Authors: Oikawa, Shota; Nomura, Hiroko; Nishio, Miki; Nagata, Rina; Hata, Tadayoshi
• Other Names: Bloch W. Academic Editor.; Tseng G.-N. Academic Editor.; Zhang Z.-M. Academic Editor.
• Is Part Of: ISRN cardiology. Volume 2014(2014)
• Publication Date: 2014-01-09
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular Diseases; Cardiovascular system -- Diseases; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.1
• DOI: 10.1155/2014/212045
• Languages: English
• ISSNs: 2090-5580

Abstract

Abstract : Objectives . Doxapram hydrochloride is a respiratory stimulant that has an inhibitory effect on myocardial IK1 potassium channels and is thought to increase membrane instability and excitability in myocardial cells. We examined the arrhythmogenic effects of doxapram hydrochloride in a rat model of halothane adrenaline-induced arrhythmia. Methods . Thirteen female Wistar rats (12–14 weeks old) were used in the study. Animals were anesthetized with inhalation of halothane to permit observation of the effects of doxapram hydrochloride on halothane adrenaline-induced arrhythmia. Time-dependent changes in ECG repolarization characteristics (QT, QTc, JTp, JT, and Tp-e intervals) were studied. Results . Doxapram hydrochloride itself did not induce arrhythmia but did induce bidirectional ventricular tachycardia after addition of adrenaline. Conclusion . Drug-induced impairment of intracellular Ca 2+ regulation caused BVT in the absence of genetic abnormalities in proteins in the sarcoplasmic reticulum.