Immunologic Monitoring of Cellular Responses by Dendritic/Tumor Cell Fusion Vaccines. (26th April 2011)

• Record Type: Journal Article
• Authors: Koido, Shigeo; Homma, Sadamu; Takahara, Akitaka; Namiki, Yoshihisa; Komita, Hideo; Nagasaki, Eijiro; Ito, Masaki; Nagatsuma, Keisuke; Uchiyama, Kan; Satoh, Kenichi; Ohkusa, Toshifumi; Gong, Jianlin; Tajiri, Hisao
• Other Names: Whiteside Theresa L. Academic Editor.
• Is Part Of: Journal of biomedicine and biotechnology. Volume 2011(2011)
• Publication Date: 2011-04-26
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Medicine; Biology; Biotechnology; Médecine; Biologie; Biotechnologie; Biology; Biotechnology; Medicine; Biotechnology; Biomedicine; Electronic journals; Periodical; Periodicals; Electronic journals; 610
• DOI: 10.1155/2011/910836
• Languages: English
• ISSNs: 1110-7243

Abstract

Abstract : Although dendritic cell (DC)- based cancer vaccines induce effective antitumor activities in murine models, only limited therapeutic results have been obtained in clinical trials. As cancer vaccines induce antitumor activities by eliciting or modifying immune responses in patients with cancer, the Response Evaluation Criteria in Solid Tumors (RECIST) and WHO criteria, designed to detect early effects of cytotoxic chemotherapy in solid tumors, may not provide a complete assessment of cancer vaccines. The problem may, in part, be resolved by carrying out immunologic cellular monitoring, which is one prerequisite for rational development of cancer vaccines. In this review, we will discuss immunologic monitoring of cellular responses for the evaluation of cancer vaccines including fusions of DC and whole tumor cell.