Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes. (15th June 2010)

• Record Type: Journal Article
• Authors: Alvarez, Yolanda; Valera, Isela; Municio, Cristina; Hugo, Etzel; Padrón, Francisco; Blanco, Lydia; Rodríguez, Mario; Fernández, Nieves; Crespo, Mariano Sánchez
• Other Names: Parker Andrew Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2010(2010)
• Publication Date: 2010-06-15
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2010/201929
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE 2, PGD 2, and several cytokines including a robust IL-10 response. Zymosan activated κ B-binding activity, but inhibition of NF-κ B was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE 2, showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE 2, thus unraveling a functional cooperation between eicosanoid production and cytokine production.