Carbon-Nanofibers-Based Micro-/Nanodevices for Neural-Electrical and Neural-Chemical Interfaces. (22nd April 2012)

• Record Type: Journal Article
• Authors: Zhang, Hongzhi; Yu, Mei; Xie, Lei; Jin, Linlin; Yu, Zhe
• Other Names: Lin Tong Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2012(2012)
• Publication Date: 2012-04-22
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2012/280902
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Carbon nanofibers (CNFs) have shown great potentials for development of micro-/nanodevices for neural interfaces due to their suitable properties, such as chemical stability, good electrical conductivity, ultramicro size with low electrical impedance, 3D structures with high surface-to-volume ratio, and long-term biocompatibility. In this paper, we review the applications of CNFs as neural-electrical interfaces and neural-chemical interfaces for neural recording and stimulation, electroconductive nanofibrous scaffolds for nerve tissue engineering, drug and gene delivery, and neurochemical sensing. The CNFs-based micro-/nanodevices provide new platforms to fine-tune electrical and chemical cues of neurons at subcellular nanoscale, which can be used for both fundamental studies of material-cell interactions and the development of chronically stable, implantable neural interface devices. Further development of this technology may potentially enable a highly multiplex closed-loop system with multifunctions for neuromodulation and neuroprostheses.