Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon. (29th February 2012)

• Record Type: Journal Article
• Authors: Kimbi, Helen Kuokuo; Ntoko, Mesame; Ntonifor, Nelson N.; Lum, Emmaculate; Njunda, Anna L.; Fon, Peter Nde
• Other Names: Tanner Marcel Academic Editor.
• Is Part Of: Journal of tropical medicine. Volume 2012(2012)
• Publication Date: 2012-02-29
• Subjects: Tropical medicine -- Periodicals; 616.9883
• DOI: 10.1155/2012/372518
• Languages: English
• ISSNs: 1687-9686

Abstract

Abstract : Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess the in vivo efficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P < 0.05 ) on all days of followup. The drug combination did not give rise to any serious side effects.