Changes in Body Composition, Cardiovascular Disease Risk Factors, and Eating Behavior after an Intensive Lifestyle Intervention with High Volume of Physical Activity in Severely Obese Subjects: A Prospective Clinical Controlled Trial. (24th April 2013)

• Record Type: Journal Article
• Authors: Danielsen, Kjersti Karoline; Svendsen, Mette; Mæhlum, Sverre; Sundgot-Borgen, Jorunn
• Other Names: Weghuber Daniel Academic Editor.
• Is Part Of: Journal of obesity. Volume 2013(2013)
• Publication Date: 2013-04-24
• Subjects: Obesity -- Periodicals; Obesity; Obesity; Electronic journals; Periodicals; Periodicals; 616.398
• DOI: 10.1155/2013/325464
• Languages: English
• ISSNs: 2090-0708

Abstract

Abstract : We examined the effects of a 10–14-weeks inpatient lifestyle modification program, including minimum 90 min of physical activity (PA) five days/week, on body composition, CVD risk factors, and eating behavior in 139 obese subjects (BMI 42.6 ± 5.2 kg/m 2 ). Completion rate was 71% ( n = 71 ) in the intensive lifestyle intervention (ILI) group and 85% ( n = 33 ) among waiting list controls. Compared to controls body weight (- 17.0 (95% CI: - 18.7, - 15.3 ) kg, P < 0.0001 ), fat mass (- 15.2 (95% CI: - 17.4, - 13.1 ) kg, P < 0.0001 ), fat free mass (- 1.2 (95% CI: - 2.2, - 0.2 ) kg, P = 0.016 ) and visceral fat (- 86.6 (95% CI: - 97.4, - 75.7 ) cm 2, P < 0.0001 ) were reduced in the ILI-group after 10–14 weeks. Within the ILI-group weight loss was - 23.8 (95% CI: - 25.9, - 21.7 ) kg, P < 0.0001 and - 20.3 (95% CI: - 23.3, - 17.3 ) kg, P < 0.0001, after six and 12 months, respectively. Systolic BP, glucose, triglycerides, and LDL-C were reduced, and HDL-C was increased (all P ≤ 0.006 ) after 10–14 weeks within the ILI group. The reduction in glucose and increase in HDL-C were sustained after 12 months (all P < 0.0001 ). After one year, weight loss was related to increased cognitive restraint and decreased uncontrolled eating (all P < 0.05 ). Thus, ILI including high volume of PA resulted in weight loss with almost maintenance of fat-free mass, favorable changes in CVD risk factors, and eating behavior in subjects with severe obesity.