Transition‐Metal‐Free Synthesis of Unsymmetrical Disulfides via Three‐Component Reaction of Thiosulfonates, Thiourea and Alkyl halides. Issue 11 (9th April 2021)

• Record Type: Journal Article
• Authors: Wang, Dungai; He, Quan; Shi, Keqiang; Xiong, Mingteng; Zhou, Yifeng; Pan, Yuanjiang
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 11(2021)
• Page Start: 2767
• Page End: 2772
• Publication Date: 2021-04-09
• Subjects: transition-metal-free -- unsymmetrical disulfides -- one-pot reaction -- K2CO3-promoted; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100165
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A transition‐metal‐free approach to synthesize unsymmetrical disulfides is reported that relies on a K2 CO3 ‐promoted one‐pot reaction of thiosulfonates, thiourea and alkyl halides under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsymmetrical disulfides in moderate to excellent yields. More importantly, the late‐stage modification of natural products and drug molecules was also achieved. Abstract :