"Back‐to‐Front" Type Synthesis of Polyfunctionalized Indazoles: Nitromethane Mediated, Domino Benzannulation of o‐Chloropyrazolyl Ynones. Issue 11 (31st March 2021)

• Record Type: Journal Article
• Authors: Beesu, Mallesh; Mehta, Goverdhan
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 11(2021)
• Page Start: 2877
• Page End: 2887
• Publication Date: 2021-03-31
• Subjects: Back-to-Front benzannulation -- tandem Michael-SNAr process -- transition-metal-free -- chloropyrazolyl ynones -- poly-functional indazoles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100170
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A one‐pot domino benzannulation protocol involving strapping of o‐chloropyrazolyl ynones with various nitromethane derivatives has been devised as a entry to diversely functionalized indazole frameworks. These preparatively useful transformations proceed via tandem Michael addition‐intramolecular SN Ar reaction pathway to efficiently furnish a range of functionally enriched indazoles with bioactivity potential from readily accessible precursors. Abstract :