P-Terphenyls and actinomycins from a Streptomyces sp. associated with the larva of mud dauber wasp. Issue 11 (3rd June 2021)

• Record Type: Journal Article
• Authors: Lu, Dan-Dan; Ren, Jin-Wei; Du, Qian-Qian; Song, Ya-Jie; Lin, Shi-Qi; Li, Xia; Li, Er-Wei; Xie, Wei-Dong
• Is Part Of: Natural product research. Volume 35:Issue 11(2021)
• Page Start: 1869
• Page End: 1873
• Publication Date: 2021-06-03
• Subjects: Terphenyl -- actinomycin -- Streptomyces -- strepantibin -- breast cancer -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1639177
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural p -terphenyl glycosides, strepantibin D (1 ) and strepantibin E (2 ), along with terferol (3 ), actinomycin D (4 ), actinomycin V (5 ) and actinomycin V0β (6 ), were identified from the fermentation medium of a Streptomyces sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (1 ), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural p -terphenyl in this research. Strepantibin D (1 ) and terferol (3 ) showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins (4 -6 ), especially actinomycin V (5 ), displayed remarkable cytotoxicity against breast cancer cells, with IC50 values ranging from 0.83 nM to 369.90 nM. Graphical Abstract: UF0001