Health implication of vitamin D on the cardiovascular and the renal system. (4th May 2021)

• Record Type: Journal Article
• Authors: Al-Ishaq, Raghad Khalid; Kubatka, Peter; Brozmanova, Martina; Gazdikova, Katarina; Caprnda, Martin; Büsselberg, Dietrich
• Is Part Of: Archives of physiology and biochemistry. Volume 127:Number 3(2021)
• Page Start: 195
• Page End: 209
• Publication Date: 2021-05-04
• Subjects: Vitamin D deficiency -- cardiovascular diseases -- VDR -- immune system -- renal system; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2019.1628064
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Vitamin D regulates the calcium and phosphorus balance in the body. The activated form of vitamin D (1 α, 25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. In the cardiovascular system, the vitamin D receptor is present in cardiomyocytes and the arterial wall. A clear correlation between vitamin D level and cardiovascular diseases is established. Vitamin D deficiency affects the renin-angiotensin system leading to ventricular hypertrophy and eventually to stroke. While clinical trials highlighted the positive effects of vitamin D supplements on cardiovascular disease these still need to be confirmed. This review outlines the association between vitamin D and cardiovascular and renal disease summarising the experimental data of selective cardiovascular disorders.