Cytotoxic steroidal saponins from the roots and rhizomes of Maianthemum henryi. Issue 11 (3rd June 2021)

• Record Type: Journal Article
• Authors: Zhang, Xin; Sun, Jing; Zhang, Xiaofei; Zhang, Shuo; Zhang, Xuan; Xue, Xuanji; Guo, Zengjun
• Is Part Of: Natural product research. Volume 35:Issue 11(2021)
• Page Start: 1808
• Page End: 1815
• Publication Date: 2021-06-03
• Subjects: Maianthemum henryi -- henryioside F -- henryioside G -- structure determination -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1641812
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Henryiosides F and G (1 and 2 ), two new steroidal saponins along with two known analogues (3 and 4 ) were obtained from the roots and rhizomes of Maianthemum henryi . Their structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D-NMR, IR and HR-ESI-MS data analysis. Cytotoxic activity in human HepG2 and SW620 tumour cells were evaluated by the MTT method and all of the saponins exhibited cytotoxicity with IC50 values ranging from 15.33 μ M to 57.85 μ M. Graphical Abstract: UF0001