LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1. Issue 9 (3rd May 2021)

• Record Type: Journal Article
• Authors: Shen, Weiyu; Hong, Xunyu; Jin, Chenghua; Xi, Yong
• Is Part Of: Cell cycle. Volume 20:Issue 9(2021)
• Page Start: 829
• Page End: 838
• Publication Date: 2021-05-03
• Subjects: Non-small cell lung cancer -- psmg3-as1 -- miR-613 -- sphk1; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2021.1900499
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: PSMG3-AS1 is a characterized oncogenic lncRNA in breast cancer, while its role in other cancers remains unclear. This study was to investigate the role and underlying mechansim of PSMG3-AS1 in non-small cell lung cancer (NSCLC). In this study, we found that PSMG3-AS1 could interact with miR-613. The expression of PSMG3-AS1 was upregulated in NSCLC, while the expression of miR-613 was downregulated in NSCLC. However, PSMG3-AS1 and miR-613 were not significantly correlated with each other. In NSCLC cells, PSMG3-AS1 and miR-613 overexpression failed to regulate the expression of each other. Interestingly, PSMG3-AS1 overexpression led to upregulated SphK1, a downstream target of miR-613. In addition, PSMG3-AS1 overexpression reduced the inhibitory effects of miR-613 on NSCLC cell proliferation. Therefore, PSMG3-AS1 may promote the proliferation of NSCLC cells by sponging miR-613 to upregulate SphK1.