Property study of a new silica nanoparticle delivery system of hydrophobic phthalocyanine using spectroscopic method. Issue 3 (2011)

• Record Type: Journal Article
• Authors: Lin, Rui; Zhou, Lin; Lin, Yun; Wang, Ao; Zhou, Jia Hong; Wei, Shao Hua
• Is Part Of: Spectroscopy. Volume 26:Issue 3(2011)
• Page Start: 179
• Page End: 185
• Publication Date: 2011
• Subjects: Phthalocyanine -- nanocomposites -- photodynamic therapy -- ceramics
• DOI: 10.3233/SPE-2011-0536
• Languages: English
• ISSNs: 0712-4813

Abstract

Abstract : Tetra-tert-butyl zinc(II) phthalocyanine has attracted great attention as an effective photosensitizer in the field of photodynamic therapy. However, tetra-tert-butyl zinc(II) phthalocyanine is hydrophobic and trends to aggregate to form the inactive congeries in aqueous solution, which dramatically reduce its photodynamic activity. To solve this problem, tetra-tert-butyl zinc(II) phthalocyanine was encapsulated into silica nanoparticles using microemulsion method and its properties were studied using spectroscopic methods. After embedded inside the silica nanoparticles, the water-solubility, stability and monomer percent of phthalocyanine in water were greatly improved comparing with the free phthalocyanines, and therefore, its photo-induced singlet oxygen generation efficacy of drug-doped silica nanoparticles was improved. The results indicated that encapsulation hydrophobic phthalocyanine into silica nanoparticles was an effective way to solve their problems and promote their clinical application.