New solid form of Norfloxacin: Structural studies. Issue 1 (2011)

• Record Type: Journal Article
• Authors: Bratu, I.; Borodi, G.; KacsÓ, Iren; Moldovan, Z.; Filip, C.; Dragan, Felicia; Vasilescu, M.; Simon, S.
• Is Part Of: Spectroscopy. Volume 25:Issue 1(2011)
• Page Start: 53
• Page End: 62
• Publication Date: 2011
• Subjects: FTIR -- powder X-ray diffraction -- DSC -- MS -- 13C NMR -- Norfloxacin – acetic acid solvate
• DOI: 10.3233/SPE-2010-0492
• Languages: English
• ISSNs: 0712-4813

Abstract

Abstract : The aim of the present paper was to obtain new solid forms of Norfloxacin. For this purpose Norfloxacin was recrystallized from: acetic acid and its mixtures with several organic solvents. By recrystallization of Norfloxacin from acetic acid and from its mixture with several organic solvents a new solvate was found. To evidence this new solid form of Norfloxacin different investigation techniques were used: powder X-ray diffraction, FTIR, DSC, 13 C NMR spectroscopy and mass spectrometry. The solvate is consisting on Norfloxacin and acetic acid in 1:1 molar ratio and crystallizes in triclinic system and the cell parameters were determined also.