How accurate is C‐reactive protein in diagnosing rheumatoid arthritis?. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: Murphy, Lee; Cooper, Samantha; Kuruvilla, Sarah; Tompkins, Robert B.
• Is Part Of: Evidence-based practice. Volume 21:Issue 7(2018)
• Publication Date: 2018-07
• DOI: 10.1097/01.EBP.0000545210.37227.6f
• Languages: English
• ISSNs: 1095-4120

Abstract

Abstract : EVIDENCE‐BASED ANSWER : In patients with clinical findings consistent with rheumatoid arthritis (RA), a C‐reactive protein (CRP) level of more than 0.06 mg/dL is modestly useful for ruling in, but is not useful for ruling out RA when obtained within 3 and 24 months of symptoms onset (SOR: B, prospective cohort study). CRP measurements in the years prior to diagnosis of RA do not accurately predict progression to RA (SOR: B, prospective cohort study). Elevated CRP is more sensitive but less specific than rheumatoid factor, anti‐cyclic citrullinated protein (anti‐CCP), and erythrocyte sedimentation rate (ESR) for the diagnosis of RA (SOR: B, cross‐sectional survey).