Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort. Issue 11 (14th November 2020)

• Record Type: Journal Article
• Authors: Kim, So Young; Bang, Woo Jin; Min, Chanyang; Choi, Hyo Geun
• Is Part Of: BMJ open. Volume 10:Issue 11(2020)
• Publication Date: 2020-11-14
• Subjects: nephrolithiasis -- myocardial ischemia -- stroke -- risk factors -- cohort studies; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-040034
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: The aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis. Design: A longitudinal follow-up study. Setting: Data from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify the occurrence of nephrolithiasis. Participants and interventions: In total, 19 103 patients with nephrolithiasis were matched at a 1:4 ratio with control participants for age, sex, income and region of residence. Primary and secondary outcome measures: The occurrence of stroke and ischaemic heart disease was analysed in both patients with nephrolithiasis and control participants. The primary outcome was HRs of stroke and ischaemic heart disease in a stratified Cox proportional hazards model. Smoking, alcohol consumption, obesity and Charlson Comorbidity Index were adjusted for as covariates. Subgroup analyses according to age and sex were also performed. Results: Eight per cent (1615/19 103) of patients with nephrolithiasis and 7.2% (5476/76 412) of control participants had stroke. Nine per cent (1879/19 103) of patients with nephrolithiasis and 7.7% (5895/76 412) of control participants had ischaemic heart disease. Patients with nephrolithiasis had risks of stroke and ischaemic heart disease that were 1.18 times (95% CI=1.11 to 1.24) and 1.24 times (95% CI=1.18 to 1.31) those of the control participants, respectively. The age and sex subgroups showed consistent results. Conclusions: Nephrolithiasis was associated with increased risks of stroke and ischaemic heart disease.