Are phosphodiesterase inhibitors effective and safe for men with diabetes and erectile dysfunction?. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Bayerman, Boris; Glass, Gina G.; Aggarwal, Aarti
• Is Part Of: Evidence-based practice. Volume 21:Issue 2(2018)
• Publication Date: 2018-02
• DOI: 10.1097/01.EBP.0000541980.93838.0f
• Languages: English
• ISSNs: 1095-4120

Abstract

Abstract : EVIDENCE‐BASED ANSWER : Yes. As‐needed use of sildenafil, tadalafil, and vardenafil lead to large improvements in erectile function in men with diabetes. Tadalafil taken daily results in nearly 20% more men able to complete intercourse, but only marginal clinical benefit in overall erectile function compared with placebo. Adverse events occur up to twice as often with phosphodiesterase type 5 (PDE‐5) inhibitors than placebo, but are minor such as headache and dyspepsia (SOR: A, meta‐analyses of RCTs). Vardenafil taken daily improves global erectile function scores, with mean scores at the level considered to be normal erectile function (SOR: B, single RCT).