What is the best management of ovarian failure in women with Turner syndrome?. Issue 7 (July 2017)

• Record Type: Journal Article
• Authors: Tichenor, Vincent; Snyder, Matthew
• Is Part Of: Evidence-based practice. Volume 20:Issue 7(2017)
• Publication Date: 2017-07
• DOI: 10.1097/01.EBP.0000541760.56201.69
• Languages: English
• ISSNs: 1095-4120

Abstract

Abstract : EVIDENCE‐BASED ANSWER : Parenteral estrogen starting at age 12 is associated with about 6 cm more growth than oral estrogen (SOR: B, cohort study). It is unclear if starting parenteral estrogen at age 12 or 14 makes a difference (SOR: B, underpowered RCT). Transdermal estrogen therapy is associated with achieving at least Tanner stage 4 and more growth than expected by historical standards. All patients with Turner syndrome should receive estrogen at age 12 and cyclic progesterone 2 years later to induce sexual maturity (SOR: C, expert opinion).