Abstract : Evidence‐Based Answer : Tacrolimus suspension is an effective treatment for severe allergic conjunctivitis that is refractory to common first‐line agents (SOR: B, small RCT). Topical cyclosporine (SOR: A, meta‐analysis), topical alcaftadine, and topical cromolyn (SOR: B, single RCTs) also reduce symptoms of allergic conjunctivitis.