A fatal case of COVID-19-associated invasive pulmonary aspergillosis. Issue 7 (July 2021)

• Record Type: Journal Article
• Authors: Iwanaga, Yuto; Kawanami, Toshinori; Yamasaki, Kei; Sakakibara, Hideki; Ikushima, Issei; Ikegami, Hiroaki; Tahara, Masahiro; Akata, Kentaro; Mukae, Hiroshi; Yatera, Kazuhiro
• Is Part Of: Journal of infection and chemotherapy. Volume 27:Issue 7(2021)
• Page Start: 1102
• Page End: 1107
• Publication Date: 2021-07
• Subjects: COVID-19 associated invasive pulmonary aspergillosis -- COVID-19 -- Acute respiratory distress syndrome; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2021.03.024
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.