Recent Penile Sexual Contact Is Associated With an Increased Odds of High-Risk Cervical Human Papillomavirus Infection in Transgender Men. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Deutsch, Madeline B.; Reisner, Sari L.; Peitzmeier, Sarah; Potter, Jennifer; Pardee, Dana; Hughto, Jaclyn M.W.
• Is Part Of: Sexually transmitted diseases. Volume 47:Issue 1(2020)
• Publication Date: 2020-01
• Subjects: Sexually transmitted diseases -- Periodicals; Sexual health -- Periodicals; 616.951005
• DOI: 10.1097/OLQ.0000000000001072
• Languages: English
• ISSNs: 0148-5717

Abstract

Abstract : Background: Transgender men (TM) have a male, masculine, or nonfemale gender identity, yet were assigned female sex at birth on the basis of their external genitalia. The majority of TM are at risk of infection with one of several high-risk strains of the human papillomavirus (hr-HPV), acquired primarily through sexual contact, that cause 99.7% of cervical cancers. This study aimed to explore the association between sexual behaviors and current cervical hr-HPV infection in TM with a cervix. Methods: The primary aim of this analysis was to test for an association between participant self-report of sexual contact with a penis in the past 1 year and current infection with cervical hr-HPV as measured by provider-collected cervical HPV DNA assay. This is a secondary analysis of a bio-behavioral sexual health study conducted at a health center in Boston, MA from 2015 to 2016. Analysis was conducted using logistic regression with significance level set at P less than 0.05; the primary analysis was adjusted for self-reported age, current tobacco use, years of testosterone use, and HPV vaccination status. Results: Overall prevalence of hr-HPV was 15.9%. In adjusted analyses, participants reporting receptive penile vaginal sex with any of their most recent 3 sexual partners in the past 12 months had more than 5 times greater odds of current hr-HPV infection than those reporting no penile sex of any kind during this timeframe (odds ratio, 5.23; 95% confidence interval, 1.61–17.02). Conclusions: Vaginal-receptive penile sex in the last 12 months was associated with a 5-fold increased odds of cervical high-risk HPV infection among TM. Findings can inform future population level study of associations between sexual behaviors and hr-HPV risk, which could lead to more individualized approaches to screening. Abstract : A study of cervical cancer screening in transgender men in Boston, MA, found those who reported receptive penile-vaginal sex with at least one of their most recent three sexual partners in the past year had more than 5 times the odds of a current high-risk cervical human papillomavirus infection as were those reporting no receptive vaginal sex in this same time frame.